Recombinant HIV1 gp120 protein (ab73769)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: WB, ELISA
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Product name
Recombinant HIV1 gp120 protein
See all HIV1 gp120 proteins and peptides -
Biological activity
ab73769 is immunoreactive with all sera of HIV1 infected individuals. -
Purity
> 95 % SDS-PAGE.
Purity is greater than 95.0% as determined by RP-HPLC and SDS-PAGE. -
Expression system
Escherichia coli -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Amino acids
30 to 110 -
Additional sequence information
HIV-1 gp120 is a non-glycosylated polypeptide chain, containing HIV-1 gp120 N-terminus immunodominant regions, 30-110 amino acids. The protein is fused to a six histidines tag.
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Preparation and Storage
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Alternative names
- Glycoprotein 120
- gp120
- SU
- Surface protein
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Relevance
HIV1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4, which inactivates the host adaptive immune response. -
Cellular localization
Envelope surface glycoprotein.
