Razoxane (ICRF-159), PDGF beta-receptor inhibitor (ab145979)
Key features and details
- Potent, cell-permeable, reversible, ATP-competitive PDGF β-receptor inhibitor. Topoisomerase II inhibitor.
- CAS Number: 21416-67-1
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Razoxane (ICRF-159), PDGF beta-receptor inhibitor -
Description
Potent, cell-permeable, reversible, ATP-competitive PDGF β-receptor inhibitor. Topoisomerase II inhibitor. -
Alternative names
- ICRF-159
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Biological description
Potent, cell-permeable, reversible, ATP-competitive PDGF β-receptor inhibitor. Topoisomerase II inhibitor. Shows antiangiogenic, antimetastatic and antiproliferative and antitumor effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
21416-67-1 -
Chemical structure
Properties
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Chemical name
4-[2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione -
Molecular weight
268.27 -
Molecular formula
C11H16N4O4 -
PubChem identifier
30623 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2 -
Source
Synthetic
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Research areas
