Ramatroban (BAY u 3405), Dual CRTH2 and TXA2 receptor antagonist (ab142763)
Key features and details
- Dual CRTH2 and potent TXA2 receptor antagonist
- CAS Number: 116649-85-5
- Purity: > 98%
Soluble in DMSO (30 mg/ml), Ethanol (30 mg/ml), DMF (30 mg/ml)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ramatroban (BAY u 3405), Dual CRTH2 and TXA2 receptor antagonist -
Description
Dual CRTH2 and potent TXA2 receptor antagonist -
Alternative names
- BAY u 3405
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Biological description
Dual CRTH2 and potent TXA2 receptor antagonist (Ki values are 4.3 and 4.5 nM at CRTH2 and TXA2 receptors respectively). Reduces antigen-induced inflammatory responses in vivo. Orally active. -
Purity
> 98% -
CAS Number
116649-85-5 -
Chemical structure
Properties
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Chemical name
3-[(3R)-3-[(4-Fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid
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Molecular weight
416.47 -
Molecular formula
C21H21FN2O4S -
PubChem identifier
123879 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO (30 mg/ml), Ethanol (30 mg/ml), DMF (30 mg/ml)
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CC2=C(CC1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O)O -
Source
Synthetic
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Research areas
