Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™ (ab120476)
Key features and details
- Negative control for MiTMAB™ and OcTMAB™
- CAS Number: 43016-78-0
- Soluble in DMSO to 25 mM and in ethanol to 100 mM
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Pro-myristic acid, Negative control for MiTMAB™ and OcTMAB™ -
Description
Negative control for MiTMAB™ and OcTMAB™ -
Biological description
Negative control molecule for use with MiTMAB™ ab120466 and OcTMAB™ ab120467. Pro-myristic acid is an in vitro inhibitor of dynamin I and II, targeting the PH (lipid binding) domain (IC50 = 9.2 µM for inhibition of dynamin I GTPase). Although cell-permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor (IC50 = ≥300 μM for receptor-mediated endocytosis). It can therefore be used as a negative control in cell-based studies with MiTMAB™ and/or OcTMAB™.
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General notes
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. -
CAS Number
43016-78-0 -
Chemical structure
Properties
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Chemical name
2-(Dimethylamino)ethyl tetradecanoate -
Molecular weight
299.50 -
Molecular formula
C18H37NO2 -
PubChem identifier
96645 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CCOC(=O)CCCCCCCCCCCCC -
Source
Synthetic
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Research areas
