Prednisolone sodium phosphate, glucocorticoid (ab142456)
Key features and details
- Water-soluble glucocorticoid
- CAS Number: 125-02-0
- Purity: > 98%
Soluble in water (250 mg/ mL), methanol (77 mg/mL) and ethanol.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Prednisolone sodium phosphate, glucocorticoid -
Description
Water-soluble glucocorticoid -
Biological description
Water-soluble glucocorticoid. Anti-inflammatory agent. Orally active. Active in vitro and in vivo. -
Purity
> 98% -
General notes
Prednisolone is a derivative of cortisol and a metabolite of prednisone; it exhibits immunosuppressive and anti-inflammatory activities. Prednisolone activates glucocorticoid receptors and is clinically used to treat inflammatory and autoimmune disorders. In mononuclear cells from subjects with multiple sclerosis, prednisolone decreases expression of T-bet, IFNγ, and phosphorylated STAT1, decreasing lymphocyte apoptosis. Additionally, prednisolone delays the progression of Duchenne muscular dystrophy (DMD), altering muscle fiber types in vivo.
This product is a white to off white powder.
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CAS Number
125-02-0 -
Chemical structure
Properties
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Chemical name
Disodium [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
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Molecular weight
484.39 -
Molecular formula
C21H27Na2O8P -
PubChem identifier
441409 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water (250 mg/ mL), methanol (77 mg/mL) and ethanol.
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC12CC(C3C(C1CCC2(C(=O)COP(=O)([O-])[O-])O)CCC4=CC(=O)C=CC34C)O.[Na+].[Na+] -
Source
Synthetic
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Research areas
