PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors (ab120559)
Key features and details
- Positive allosteric modulator for the α7 nicotinic acetylcholine receptor
- CAS Number: 501925-31-1
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors -
Description
Positive allosteric modulator for the α7 nicotinic acetylcholine receptor -
Biological description
Competitive, type II positive allosteric modulator for α7nAChR (EC50 = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.
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Purity
> 99% -
CAS Number
501925-31-1 -
Chemical structure
Properties
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Chemical name
N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)urea -
Molecular weight
311.72 -
Molecular formula
C13H14ClN3O4 -
PubChem identifier
311434 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC(=NO1)NC(=O)NC2=CC(=C(C=C2OC)OC)Cl -
Source
Synthetic
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Research areas
