Phlorizin, SGLT inhibitor (ab143144)
Key features and details
- Potent, competitive SGLT inhibitor
- CAS Number: 60-81-1
- Purity: > 99%
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Phlorizin, SGLT inhibitor -
Description
Potent, competitive SGLT inhibitor -
Biological description
Potent, competitive SGLT inhibitor (IC50 values are 400 and 65 nM for SGLT1 and SLGT2 respectively). Induces renal glycosuria and blocks intestinal glucose absorption in vivo. Orally active. -
Purity
> 99% -
CAS Number
60-81-1 -
Chemical structure
Properties
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Chemical name
1-[2,4-Dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one -
Molecular weight
436.41 -
Molecular formula
C21H24O10 -
PubChem identifier
6072 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble to 100 mM in DMSO and to 100 mM in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)O)O -
Source
Synthetic
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Research areas