Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist (ab144619)
Key features and details
- Irreversible calmodulin antagonist and potent, nonselective, irreversible α-adrenoceptor antagonist
- CAS Number: 63-92-3
- Purity: > 95%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Phenoxybenzamine hydrochloride, calmodulin and alpha-adrenoceptor antagonist -
Description
Irreversible calmodulin antagonist and potent, nonselective, irreversible α-adrenoceptor antagonist -
Biological description
Irreversible calmodulin antagonist (IC50 ~ 80 µM) and potent, nonselective, irreversible α-adrenoceptor antagonist (IC50 = 550 nM). Antihypertensive and anti-inflammatory effects in vitro and in vivo. Cell-permeable. Blood-brain barrier impermeable. -
Purity
> 95% -
CAS Number
63-92-3 -
Chemical structure
Properties
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Chemical name
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride -
Molecular weight
340.29 -
Molecular formula
C18H22ClNO.HCl -
PubChem identifier
5284441 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl -
Source
Synthetic
