PD 184352 (CI-1040), ATP non-competitive MEK1/2 inhibitor (ab141348)
Key features and details
- Potent, highly selective ATP non-competitive MEK1/2 inhibitor
- CAS Number: 212631-79-3
- Purity: > 99%
- Soluble in DMSO 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PD 184352 (CI-1040), ATP non-competitive MEK1/2 inhibitor -
Description
Potent, highly selective ATP non-competitive MEK1/2 inhibitor -
Alternative names
- PD184352
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Biological description
Potent, highly selective ATP non-competitive MEK1/2 inhibitor. Prevents ERK phosphorylation (IC50 = 100-500 nM) and subsequent signalling. Enhances cisplatin (ab141398) dependent apoptosis. Shows antitumor effects in vivo. Orally active.
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Purity
> 99% -
CAS Number
212631-79-3 -
Chemical structure
