PD 153035, EGFR inhibitor (ab141839)
Key features and details
- Highly potent and selective EGFR inhibitor
- CAS Number: 153436-54-5
- Purity: > 99%
- Soluble in DMSO to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PD 153035, EGFR inhibitor -
Description
Highly potent and selective EGFR inhibitor -
Biological description
Highly potent and selective EGFR inhibitor (IC50 = 25 pM). Antiproliferative and antitumor effects in vivo. -
Purity
> 99% -
CAS Number
153436-54-5 -
Chemical structure
Images
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Functional Studies - PD 153035, EGFR inhibitor (ab141839)PD 153035 inhibits EGF receptor activation in 3T3-L1 cells.
Cells were serum starved for 3 h and preincubated with different concentrations of PD 153035 (ab141839) for 2 h. The cells were then stimulated with 200 ng/ml EGF for 10 minutes. Cell proteins were resolved by SDS-PAGE and probed with anti-phospho-EGFr (upper panel) and with anti-phospho ERK1/2 (lower panel).