Paxilline, Ca2+-activated K+channel blocker (ab141840)
Key features and details
- Potent high-conductance Ca2+-activated K+channel blocker
- CAS Number: 57186-25-1
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Penicillium paxilli
Overview
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Product name
Paxilline, Ca2+-activated K+channel blocker -
Description
Potent high-conductance Ca2+-activated K+channel blocker -
Biological description
Potent high-conductance Ca2+-activated K+channel blocker (Ki = 2 nM, α-subunit BKCa)Inhibits sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 5 - 50 μM). Shows anticonvulsant effects in vivo. -
Purity
> 98% -
CAS Number
57186-25-1 -
Chemical structure
Properties
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Chemical name
(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one -
Molecular weight
435.60 -
Molecular formula
C27H33NO4 -
PubChem identifier
105008 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O -
Source
Penicillium paxilli
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Research areas
