Ouabain octahydrate, Na+/K+ ATPase inhibitor (ab120748)
Key features and details
- Na+/K+ ATPase inhibitor
- CAS Number: 11018-89-6
- Purity: > 97%
- Soluble in DMSO to 100 mM, in ethanol to 10 mM and in water to 10 mM.
- Form / State: Solid
- Source: ripe seeds of African plants Strophanthus gratus and the bark of Acokanthera ouabaio
Overview
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Product name
Ouabain octahydrate, Na+/K+ ATPase inhibitor -
Description
Na+/K+ ATPase inhibitor -
Biological description
Na+/K+ ATPase inhibitor (Ki = 30 μM). Cardiac glycoside. Stimulates activity at low nanomolar concentrations in rats. Improves cardiac function in myocardial infarction rats. Centrally active following oral administration.
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Purity
> 97% -
General notes
It has been reported that an aqueous solution of this material stored overnight in a borosilicate glass vial leads to the formation of ouabain-borate complexes.
It is therefore recommended that this material is stored in a plastic vial and any contact with borosilicate glass is minimised. -
CAS Number
11018-89-6 -
Chemical structure
Properties
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Chemical name
(1β,3β,5β,11α)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide -
Molecular weight
728.78 -
Molecular formula
C29H44O12.8H2O -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM, in ethanol to 10 mM and in water to 10 mM. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
ripe seeds of African plants Strophanthus gratus and the bark of Acokanthera ouabaio
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Research areas
