Okadaic acid sodium salt, PP1 and PP2A inhibitor (ab141831)
Key features and details
- Potent, selective PP1 and PP2A inhibitor
- CAS Number: 209266-80-8
- Purity: > 98%
- Soluble in DMSO, methanol, ethanol, or acetone to 1 mM
- Form / State: Solid
- Source: Halichondria okadai
Overview
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Product name
Okadaic acid sodium salt, PP1 and PP2A inhibitor -
Description
Potent, selective PP1 and PP2A inhibitor -
Purity
> 98% -
CAS Number
209266-80-8 -
Chemical structure
Properties
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Chemical name
9,10-Deepithio-9,10-didehydroacanthifolicin sodium salt -
Molecular weight
827.00 -
Molecular formula
C44H67NaO13 -
PubChem identifier
71308608 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO, methanol, ethanol, or acetone to 1 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)[O-])O)O)C)O)O.[Na+] -
Source
Halichondria okadai
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Research areas
Images
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Functional Studies - Okadaic acid sodium salt, PP1 and PP2A inhibitor (ab141831)
Cells were grown to 70% confluence and serum starved for 18 h. For in vivo phosphatase activity, the growth medium was replaced with HENK's and the cells were preincubated in the presence or absence of 100 nM Okadaic Acid (ammonium salt) (ab141830), (or Okadaic Acid (sodium salt) (ab141831)) and 100 nM 1-Norokadaone (ab145527) followed by a 20 min incubation with or without 20 µM NEM. The cells were then stimulated with 5 ng/ml PDGF for 30 min. At the end of the incubation, cell proteins were resolved by SDS-PAGE and probed with anti-phospho-Akt antibodies.