NVP-TAE684, ALK inhibitor (ab142082)
Key features and details
- Highly potent, selective ALK inhibitor
- CAS Number: 761439-42-3
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NVP-TAE684, ALK inhibitor -
Description
Highly potent, selective ALK inhibitor -
Biological description
Highly potent, selective ALK inhibitor in vitro (IC50 = 2 nM). Suppresses lymphomagenesis in vivo. Down-regulates CD30 expression. Antitumor agent. Potent LRRK2 kinase inhibitor (IC50 = 7.8 nM). -
Purity
> 98% -
CAS Number
761439-42-3 -
Chemical structure
Properties
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Chemical name
5-Chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl] phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine -
Molecular weight
614.20 -
Molecular formula
C30H40ClN7O3S -
PubChem identifier
16038120 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN (CC5)C)OC -
Source
Synthetic
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Research areas