NU6102, CDK1/cyclin B and CDK2/cyclin A3 inhibitor (ab144317)
Key features and details
- Potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor. Antiproliferative agent.
- CAS Number: 444722-95-6
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NU6102, CDK1/cyclin B and CDK2/cyclin A3 inhibitor -
Description
Potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor. Antiproliferative agent. -
Biological description
Potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor (IC50 values are 9.5 and 5.4 nM for CDK1/cyclin B and CDK2/cyclin A3 respectively). Antiproliferative agent. Inhibits CDK4/D1, DYRK1A, PDK1 ROCKII (IC50 values are 1.6, 0.9, 0.8 and 0.6 μM respectively). Induces G2/M cell cycle arrest. Shows antitumor effects in vivo. -
Purity
> 98% -
CAS Number
444722-95-6 -
Chemical structure
Properties
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Chemical name
4-[[6-(Cyclohexylmethoxy)-7H-purin-2-yl]amino]benzenesulfonamide -
Molecular weight
402.47 -
Molecular formula
C18H22N6O3S -
PubChem identifier
4566 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)S(=O)(=O)N -
Source
Synthetic
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Research areas
