NSC 663284 (DA3003-1), Cdc25 inhibitor (ab144408)
Key features and details
- Potent, cell-permeable, irreversible non-selective Cdc25 inhibitor
- CAS Number: 383907-43-5
- Purity: > 98%
- Soluble in ethanol to 50 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NSC 663284 (DA3003-1), Cdc25 inhibitor -
Description
Potent, cell-permeable, irreversible non-selective Cdc25 inhibitor -
Alternative names
- DA3003-1
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Biological description
Potent, cell-permeable, irreversible non-selective Cdc25 inhibitor. Induces cell cycle arrest at both G1 and G2/M phase. Shows antiproliferative effects against tumor cell lines (IC50 = 0.2-35 μM). Shows antitumor effects in vivo. -
Purity
> 98% -
CAS Number
383907-43-5 -
Chemical structure
Properties
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Chemical name
6-Chloro-7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione -
Molecular weight
321.76 -
Molecular formula
C15H16ClN3O3 -
PubChem identifier
379077 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 50 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl -
Source
Synthetic
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Research areas
