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Neuroscience Neurology process Neurodegenerative disease Alzheimer's disease Tangles & Tau

NPPB, chloride channel blocker (ab141521)

Key features and details

  • Potent chloride channel blocker
  • CAS Number: 107254-86-4
  • Purity: > 99%
  • Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    NPPB, chloride channel blocker
  • Description

    Potent chloride channel blocker
  • Biological description

    Potent chloride channel blocker (IC50 = 80 nM). GPR35 agonist. Able to uncouple mitochondria. Active in vivo.

  • Purity

    > 99%
  • CAS Number

    107254-86-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Nitro-2-(3-phenylpropylamino)benzoic acid
  • Molecular weight

    300.31
  • Molecular formula

    C16H16N2O4
  • PubChem identifier

    4549
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)CCCNC2=C(C=C(C=C2)[N+](=O)[O-])C(=O)O
  • Source

    Synthetic

  • Research areas

    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Alzheimer's disease
    • Tangles & Tau
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Microtubules
    • MT Associated Proteins
    • Tau
    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipid Metabolism
    • Cytochromes
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Other
    • Neuroscience
    • Cell Type Marker
    • Neuron marker
    • Axon marker
    • Signal Transduction
    • Metabolism
    • Lipid metabolism
    • Signal Transduction
    • Metabolism
    • Drug metabolism
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipases
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Drug metabolism
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
    • Cytochromes
    • Biochemicals
    • Pharmacology
    • Ion Channels
    • Chloride
    • Blockers

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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