NNC 05-2090, GABA uptake inhibitor (ab120317)
Key features and details
- GABA uptake inhibitor
- CAS Number: 184845-43-0
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NNC 05-2090, GABA uptake inhibitor -
Description
GABA uptake inhibitor -
Biological description
GABA uptake inhibitor, selective for the BGT-1 transporter (Ki values are 1.4 (BGT-1), 19 (GAT-1), 41 (GAT-2) and 15 μM (GAT-3)). Also active at α1- and D2-receptors (IC50 values are 266 and 1632 nM, respectively). Anticonvulsant in vivo.
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Purity
> 99% -
CAS Number
184845-43-0 -
Chemical structure
Properties
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Chemical name
1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride -
Molecular weight
451.01 -
Molecular formula
C27H30N2O2.HCl -
PubChem identifier
18782760 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.COc1ccccc1C5(O)CCN(CCCn4c2ccccc2c3ccccc34)CC5 -
Source
Synthetic
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Research areas