NMS-873 (ab270807)
Key features and details
- Potent and selective VCP ATPase inhibitor
- CAS Number: 1418013-75-8
- Purity: >= 98%
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NMS-873 -
Description
Potent and selective VCP ATPase inhibitor -
Biological description
Potent and selective VCP ATPase inhibitor (IC50 = 30 nM). Selective against a range of AAA ATPases, HSP90 and kinases (IC50 >10 μM). Activator of unfolded protein response. Modulates maturatiion of autophagosomes. In vitro antiproliferative activity in cancer cell lines. Anti-viral activity towards influenza A and B.
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Purity
>= 98% -
CAS Number
1418013-75-8 -
Chemical structure
Properties
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Chemical name
3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
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Molecular weight
520.67 -
Molecular formula
C27H28N4O3S2 -
PubChem identifier
71521142 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C -
Source
Synthetic
Images
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Chemical Structure - NMS-873 (ab270807)
Chemical structure of NMS-873, 1418013-75-8