Nicastrin peptide (ab4977)
Key features and details
- Suitable for: Blocking
-
Product name
Nicastrin peptide
See all Nicastrin proteins and peptides -
Animal free
No -
Nature
Synthetic
Preparation and Storage
-
Alternative names
- Anterior pharynx defective 2
- APH 2
- APH2
see all -
Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. -
Tissue specificity
Widely expressed. -
Sequence similarities
Belongs to the nicastrin family. -
Cellular localization
Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. - Information by UniProt
