Native Staphylococcus aureus Protein A (FITC) (ab7455)
Key features and details
- Expression system: Native
- Suitable for: Flow Cyt, Immunomicroscopy
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Product name
Native Staphylococcus aureus Protein A (FITC)
See all Protein A proteins and peptides -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Staphylococcus aureus -
Predicted molecular weight
56 kDa
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Conjugation
FITC. Ex: 493nm, Em: 528nm
Preparation and Storage
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Alternative names
- gG-binding protein A
- Immunoglobulin G binding protein A
- SPA
- Staphylococcal protein A
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Relevance
Protein A is a surface protein of S.aureus which binds IgG molecules by their Fc region. In serum, the bacteria will bind IgG molecules in the wrong orientation on their surface which hinders opsonization and phagocytosis. Mutants of S. aureus lacking protein A are more efficiently phagocytosed in vitro, and mutants in infection models have diminished virulence. Due to its affinity for the Fc region of many mammalian immunoglobulins, protein A is considered a universal reagent in biochemistry and immunology. -
Cellular localization
Secreted; cell wall.
