Native Human hCG protein (ab51782)
Key features and details
- Expression system: Native
- Purity: > 95% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE
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Product name
Native Human hCG protein
See all hCG proteins and peptides -
Biological activity
The specific activity was found to be 5000 IU/mg. The biological activity of hCG is determined by using the seminal vesicle weight gain test in male rats described in the "Chorionic Gonadotrophins" monograph of the European Pharmacopoeia.
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Purity
> 95 % SDS-PAGE.
Purity: >98% as determined by SDS PAGE and HPLC. ab51782 is free of HbsAg, Hepatitis B surface antigen, and antibodies to HIV, Hepatitis C and HCV. -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Human
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Preparation and Storage
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Alternative names
- anterior pituitary glycoprotein hormones common subunit alpha
- CG alpha
- CG-ALPHA
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Relevance
Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non pregnant urine and sera. It rises sharply during pregnancy. HCG is composed of two non identical, non covalently linked polypeptide chains designated as the a and b subunits. The a subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP) and HCG but negative for EMA and AFP is probably a choriocarcinoma. -
Cellular localization
Secreted
