Native Human FXI protein (ab62538)
Key features and details
- Expression system: Native
- Suitable for: SDS-PAGE
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Product name
Native Human FXI protein -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
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Species
Human
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Preparation and Storage
-
Alternative names
- Coagulation factor XI
- Coagulation factor XIa light chain
- F11
see all -
Function
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. -
Tissue specificity
Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. -
Involvement in disease
Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. -
Sequence similarities
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain. -
Post-translational
modificationsActivated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. -
Cellular localization
Secreted. - Information by UniProt
