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Momelotinib (CYT387), ATP-competitve JAK 1/2 selective inhibitor (ab141372)

Key features and details

  • Potent ATP-competitve JAK 1/2 selective inhibitor
  • CAS Number: 1056634-68-4
  • Purity: > 95%

  • Soluble in DMSO to 20mM.

  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Momelotinib (CYT387), ATP-competitve JAK 1/2 selective inhibitor

  • Description

    Potent ATP-competitve JAK 1/2 selective inhibitor

  • Alternative names

    • CYT387

  • Biological description

    Potent ATP-competitive JAK 1/2 selective inhibitor (IC50 values are 11, 18 and 155 nM for JAK1, JAK2 and JAK3 respectively). Shows antiproliferative effects (IC50 = 4 μM, IL-3 stimulated Ba/F3 cells). Shows antitumor effects in vivo.

  • Purity

    > 95%

  • CAS Number

    1056634-68-4

  • Chemical structure

    Chemical Structure

Images

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