MitoPerOx, fluorescent mitochondria-targeted lipid peroxidation probe (ab146820)
Key features and details
- Ratiometric, fluorescent, mitochondria-targeted lipid peroxidation probe
- Purity: > 95%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
MitoPerOx, fluorescent mitochondria-targeted lipid peroxidation probe -
Description
Ratiometric, fluorescent, mitochondria-targeted lipid peroxidation probe -
Biological description
Ratiometric, fluorescent, mitochondria-targeted lipid peroxidation probe. Derived from the C11-BODIPY(581/591) probe, which contains a boron dipyromethane difluoride (BODIPY) fluorophore conjugated via a dienyl link to a phenyl group. An attached triphenylphosphonium lipophilic cation leads to selective uptake into mitochondria in living cells, driven by the mitochondrial membrane potential. In response to lipid peroxidation the fluorescence emission maximum shifts from ∼590 to ∼520 nm.
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Purity
> 95% -
Chemical structure
Properties
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Emission
590nm -
Chemical name
4,4-Difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-(propionylaminoethylentriphenylphosphonium) bromide -
Molecular weight
760.46 -
Molecular formula
C42H38BF2N3OP.Br -
Storage instructions
Store at -20°C long term. Store In the Dark. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Br-].F[B-]7(F)[N+]=2C(C=CC=2\C=C\C=C\c1ccccc1)=Cc6ccc(CCC(=O)NCC[P+](c3ccccc3)(c4ccccc4)c5ccccc5)n67 -
Source
Synthetic