Miransertib, pan-Akt inhibitor (ab235550)
Key features and details
- Allosteric, selective, non-ATP competitive pan-Akt inhibitor
- CAS Number: 1313881-70-7
- Purity: > 98%
Soluble ine DMSO to 159.92 mM and in ethanol to 8.52 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Miransertib, pan-Akt inhibitor -
Description
Allosteric, selective, non-ATP competitive pan-Akt inhibitor -
Alternative names
- ARQ-092
-
Biological description
Allosteric, selective, non-ATP competitive pan-Akt inhibitor (IC50 = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). Selective for Akt isoforms over a panel of 303 other kinases. Binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. Orally bioavailable.
-
Purity
> 98% -
CAS Number
1313881-70-7 -
Chemical structure
Properties
-
Chemical name
3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine
-
Molecular weight
432.53 -
Molecular formula
C27H24N6 -
PubChem identifier
53262401 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble ine DMSO to 159.92 mM and in ethanol to 8.52 mM
-
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1CC(C1)(C2=CC=C(C=C2)N3C4=C(C=CC(=N4)C5=CC=CC=C5)N=C3C6=C(N=CC=C6)N)N -
Source
Synthetic
