MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor (ab145601)
Key features and details
- Potent and selective cell-permeable calpain and cathepsin B inhibitor
- CAS Number: 88191-84-8
- Purity: > 95%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor -
Description
Potent and selective cell-permeable calpain and cathepsin B inhibitor -
Biological description
Potent and selective cell-permeable calpain and cathepsin B inhibitor (IC50 = 11 nM, calpain, Ki values are 10 and 25 nM for calpain and cathepsin B respectively). Shows neuroprotective effects in vivo. Blood-brain barrier permeable. -
Purity
> 95% -
CAS Number
88191-84-8 -
Chemical structure
Properties
-
Chemical name
benzyl N-[3-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]butan-2-yl]carbamate -
Molecular weight
382.45 -
Molecular formula
C22H26N2O4 -
PubChem identifier
9907994 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2 -
Source
Synthetic
-
Research areas