Maurocalcine, RyR1 agonist (ab141860)
Key features and details
- Cell-permeable, reversible RyR1 agonist
- CAS Number:
- Purity: > 98%
- Soluble in water
- Form / State: Solid
- Source: Scorpio maurus palmatus
Overview
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Product name
Maurocalcine, RyR1 agonist -
Description
Cell-permeable, reversible RyR1 agonist -
Biological description
Cell-permeable, reversible RyR1 agonist. Reversibly modifies channel gating behaviour of RyR1. Highly competitive cell-penetrating peptide. Induces intracellular Ca2+ release. -
Purity
> 98% -
Chemical structure
Properties
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Molecular weight
3864.00 -
Molecular formula
C156H260N56O46S6 -
Sequence
GDCLPHLKRCKADNDCCGKKCKRRGTNAEKRCR (Modifications: Disulfide bonds: 3-17, 10-21, 16-32) -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Scorpio maurus palmatus
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Research areas
Images
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Functional Studies - Maurocalcine, RyR1 agonist (ab141860)Maurocalcine evokes long lasting Ca2+ release events in skeletal myotubes.
Myotube cell cultures were prepared from limbs of 2 days old rat pups were loaded with 4 mM fluo-3 AM (ab145254) and then stimulated with Maurocalcine (ab141860). Ca2+ spreads in the same myotube before (A) and after (B) stimulation with 200 nM Maurocalcine.