LY 344864 hydrochloride, 5-HT1F agonist (ab120592)
Key features and details
- Selective, potent 5-HT1F agonist
- CAS Number: 186544-26-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in water to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LY 344864 hydrochloride, 5-HT1F agonist -
Description
Selective, potent 5-HT1F agonist -
Biological description
Selective, potent, full 5-HT1F agonist (EC50 = 3 nM). Selectivity is 80-fold greater than for other 5-HT receptor subtypes, Ki values are 0.53 (5-HT1A), 0.549 (5-HT1B), 0.575 (5-HT1D), 1.415 (5-HT1E), 3.935 (5-HT2A), 1.695 (5-HT2B), 3.499 (5-HT2C) and 4.851 (5-HT7). Able to reduce central sensitization and dural inflammation in vivo.
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Purity
> 98% -
CAS Number
186544-26-3 -
Chemical structure
Properties
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Chemical name
N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride -
Molecular weight
387.88 -
Molecular formula
C21H22FN3O.HCl -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in water to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
