L-threo-Dihydrosphingosine (Safingol), lyso-sphingolipid PKC inhibitor (ab144070)
Key features and details
- Cell-permeable, reversible lyso-sphingolipid protein kinase C (PKC) inhibitor
- CAS Number: 15639-50-6
- Purity: > 98%
- Soluble in ethanol and in DMSO to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
L-threo-Dihydrosphingosine (Safingol), lyso-sphingolipid PKC inhibitor -
Description
Cell-permeable, reversible lyso-sphingolipid protein kinase C (PKC) inhibitor -
Alternative names
- Safingol
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Biological description
Cell-permeable, reversible lyso-sphingolipid protein kinase C (PKC) inhibitor (IC50 = 40 µM). Anticancer agent. Potentiates effect of Doxorubicin (DOX) (ab120629) in tumor-bearing animals and cytotoxicity of Mitomycin C (ab120797) in cancer cells. Active in vivo and in vitro. -
Purity
> 98% -
CAS Number
15639-50-6 -
Chemical structure
Properties
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Chemical name
(2R,3R)-2-aminooctadecane-1,3-diol -
Molecular weight
301.51 -
Molecular formula
C18H39NO2 -
PubChem identifier
3058739 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol and in DMSO to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCCCCCCCCCCCC[C@@H]([C@H](CO)N)O -
Source
Synthetic
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Research areas
