KT5823, inhibitor of PKG (ab120423)
Key features and details
- Potent, selective inhibitor of PKG
- CAS Number: 126643-37-6
- Purity: > 95%
- Soluble in ethanol and in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
KT5823, inhibitor of PKG -
Description
Potent, selective inhibitor of PKG -
Biological description
Potent, selective, reversible inhibitor of Protein Kinase G (PKG) (Ki = 234 nM). Derivative of K252, selective over PKA and PKC (Ki values are >10 and 4 μM, respectively). Prevents increased phosphorylation of regulators of G-protein-signalling in vivo.
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Purity
> 95% -
CAS Number
126643-37-6 -
Chemical structure
Properties
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Chemical name
(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester -
Molecular weight
495.53 -
Molecular formula
C29H25N3O5 -
PubChem identifier
108152 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol and in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OC)[C@]8(C[C@H]7O[C@]8(C)n4c3c1n7c6ccccc6c1c2c(CN(C)C2=O)c3c5ccccc45)OC -
Source
Synthetic
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Research areas
