KRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole), Hsp27 inhibitor (ab146011)
Key features and details
- Selective Hsp27 inhibitor. Microtubule inhibitor.
- CAS Number: 129414-88-6
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
KRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole), Hsp27 inhibitor -
Description
Selective Hsp27 inhibitor. Microtubule inhibitor. -
Biological description
Selective Hsp27 inhibitor. Microtubule inhibitor. Inhibits PKC-dependent Hsp27-phosphorylation. Induces mitotic arrest and apoptosis in cancer cells. Shows antitumor effects in vivo. -
Purity
> 98% -
CAS Number
129414-88-6 -
Chemical structure
Properties
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Chemical name
5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole -
Molecular weight
325.36 -
Molecular formula
C19H19NO4 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCc3cc(c2oncc2c1ccc(OC)cc1)c(O)cc3OC -
Source
Synthetic
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Research areas
