Ki 8751 (ab141266)
Key features and details
- Highly potent, selective VEGFR-2 tyrosine kinase inhibitor
- CAS Number: 228559-41-9
- Purity: > 99%
≥23.45mg/mL in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ki 8751 -
Description
Highly potent, selective VEGFR-2 tyrosine kinase inhibitor -
Biological description
Highly potent, selective VEGFR-2 tyrosine kinase inhibitor (IC50 = 0.9 nM). Shows some inhibition to c-Kit, PDGFRα and FGFR-2 signaling (IC50 = 40-170 nM). Shows antiangiogenic and antitumor effects in vivo.
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Purity
> 99% -
CAS Number
228559-41-9 -
Chemical structure
Properties
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Chemical name
N-(2,4-Difluorophenyl)-N’-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
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Molecular weight
469.41 -
Molecular formula
C24H18F3N3O4 -
PubChem identifier
11317348 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
≥23.45mg/mL in DMSO
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F -
Source
Synthetic
Images
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Chemical Structure - Ki 8751 (ab141266)
Chemical structure of Ki 8751, 228559-41-9