JTE 607 dihydrochloride (ab273390)
Key features and details
- Cytokine release inhibitor
- CAS Number: 188791-09-5
- Purity: > 98%
Soluble in DMSO to 100 mM and water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
JTE 607 dihydrochloride -
Description
Cytokine release inhibitor -
Biological description
Inhibits inflammatory cytokine production in human peripheral blood mononuclear cells (PBMC’s), e.g. IC50’s = 11 nM (TNF-α), 5.9 nM (IL-1β), 8.8 nM (IL-6), 7.3 nM (IL-8), and 9.1 nM (IL-10). Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.
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Purity
> 98% -
CAS Number
188791-09-5 -
Chemical structure
Properties
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Chemical name
Ethyl ester-N-[3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1- piperazinyl)ethoxy]benzoyl]-L-phenylalanine, dihydrochloride
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Molecular weight
597.36 -
Molecular formula
C23H33Cl2N3O5.2HCl -
PubChem identifier
9938544 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
Soluble in DMSO to 100 mM and water to 100 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=CC(=C(C(=C2O)Cl)OCCN3CCN(CC3)C)Cl.Cl.Cl -
Source
Synthetic
Images
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Chemical Structure - JTE 607 dihydrochloride (ab273390)
Chemical structure of JTE 607 dihydrochloride, 188791-09-5