IU1, Usp14 inhibitor. Cell-permeable (ab142122)
Key features and details
- Selective, reversible Usp14 inhibitor. Cell-permeable
- CAS Number: 314245-33-5
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
IU1, Usp14 inhibitor. Cell-permeable -
Description
Selective, reversible Usp14 inhibitor. Cell-permeable -
Biological description
Selective, reversible Usp14 inhibitor (IC50 = 4 μM). Enhances degradation of proteasome substrates. Reduces rate of ubiquitin chain trimming bound to cyclin B or other ubiquitin chains. Active in vitro. Cell-permeable. -
Purity
> 98% -
CAS Number
314245-33-5 -
Chemical structure
Properties
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Chemical name
1-[1-(4-Fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone -
Molecular weight
300.37 -
Molecular formula
C18H21FN2O -
PubChem identifier
675434 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3 -
Source
Synthetic
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Research areas
