ITE (ab231512)
Key features and details
- An endogenous aryl hydrocarbon receptor (AhR) agonist
- CAS Number: 448906-42-1
- Purity: > 98%
Soluble in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ITE -
Description
An endogenous aryl hydrocarbon receptor (AhR) agonist -
Alternative names
- 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester
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Biological description
Endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Enhances differentiation of cancer stem like cells detected by the decrease of sphere formation and proliferation from glioblastoma cells U87. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Inhibits TGF-β-induced human myofibroblast differentiation.
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Purity
> 98% -
General notes
Protect from air and light.
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CAS Number
448906-42-1 -
Chemical structure
Properties
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Chemical name
Methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate
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Molecular weight
286.31 -
Molecular formula
C14H10N2O3S -
PubChem identifier
4668801 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. -
Solubility overview
Soluble in DMSO to 75 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC(=O)C1=CSC(=N1)C(=O)C2=CNC3=CC=CC=C32 -
Source
Synthetic
