IMD 0354, IKKbeta inhibitor (ab144823)
Key features and details
- Potent, selective cell-permeable IKKβ inhibitor
- CAS Number: 978-62-1
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
IMD 0354, IKKbeta inhibitor -
Description
Potent, selective cell-permeable IKKβ inhibitor -
Biological description
Potent, selective cell-permeable IKKβ inhibitor (IC50 = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo. -
Purity
> 99% -
CAS Number
978-62-1 -
Chemical structure
Properties
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Chemical name
N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide -
Molecular weight
383.67 -
Molecular formula
C15H8ClF6NO2 -
PubChem identifier
5081913 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 25 mM -
Handling
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SMILES
Oc2ccc(Cl)cc2C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F -
Source
Synthetic
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Research areas
