Imatinib mesylate, Tyrosine kinase inhibitor (ab142070)
Key features and details
- Potent, selective tyrosine kinase inhibitor
- CAS Number: 220127-57-1
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Imatinib mesylate, Tyrosine kinase inhibitor -
Description
Potent, selective tyrosine kinase inhibitor -
Alternative names
- 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate
- CGP 57148
- CGP 57148B
see all -
Biological description
Potent, selective inhibitor of tyrosine kinases v-Abl (IC50 = 38 nM), PDGFR and c-kit. Potent inhibitor of the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality found in CML. Decreases proliferation and enhances apoptosis in leukemias CML and ALL.
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Purity
> 98% -
CAS Number
220127-57-1 -
Chemical structure
