Ikarugamycin, clathrin-dependent endocytosis inhibitor (ab143408)
Key features and details
- Antibiotic agent. Clathrin-dependent endocytosis inhibitor.
- CAS Number: 36531-78-9
- Purity: > 98%
- Soluble in DMSO to 10 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ikarugamycin, clathrin-dependent endocytosis inhibitor -
Description
Antibiotic agent. Clathrin-dependent endocytosis inhibitor. -
Biological description
Antibiotic agent. Inhibits clathrin-dependent endocytosis. Shows antiprotozoal (IC50 = 0.3-1.25 μM) and cytotoxic effects (IC50 = 221 nM). -
Purity
> 98% -
CAS Number
36531-78-9 -
Chemical structure
Properties
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Chemical name
(2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-3-Ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-14,17-metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione -
Molecular weight
478.63 -
Molecular formula
C29H38N2O4 -
PubChem identifier
57369669 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCC1C(CC2C1C=CC3C2CC4C3CC=CC(=O)NCCCC5C(=O)C(=C(C=C4)O)C(=O)N5)C -
Source
Synthetic
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Research areas