Astana Biomed Group, an authorized Abcam distributor in Central Asia

Human DLL3 knockout HEK293T cell pellet (ab279136)

Overview

  • Product name

    Human DLL3 knockout HEK293T cell pellet
    See all DLL3 kits

  • Product overview

    Abcam’s knockout cell pellets give you access to native proteins, without the need to culture cells. Our knockout cell pellets are prepared from our single-gene knockout cell lines and provide an additional offering to our cell lysates.

    Cells are snap-frozen to provide high quality pellets that are suitable for extraction with alternative lysis buffers or for preparation of lysates from subcellular fractions. Our knockout cell pellets are suitable for a variety of applications, including PCR, gene expression profiling and DNA library preparation.

  • Parental Cell Line

    HEK293T

  • Organism

    Human

  • Mutation description

    Knockout achieved by using CRISPR/Cas9, 1 bp insertion in exon3.

  • Passage number

  • Knockout validation

    Sanger Sequencing

  • Notes

    Pellet size: 5 million cells/vial.

    This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our limited use license and patent pages.

Properties

Target

  • Function

    Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.

  • Involvement in disease

    Spondylocostal dysostosis 1

  • Sequence similarities

    Contains 1 DSL domain.
    Contains 6 EGF-like domains.

  • Domain

    The DSL domain is required for binding to the Notch receptor.

  • Post-translational
    modifications

    Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

  • Cellular localization

    Membrane.
  • Information by UniProt

  • Alternative names

    • Delta Drosophila like 3
    • Delta like 3 Drosophila
    • Delta like 3 homolog Drosophila
    • Delta like 3 protein
    • Delta like protein 3 precursor
    • Delta-like protein 3
    • Delta3
    • Dll3
    • DLL3_HUMAN
    • Drosophila Delta homolog 3
    • SCDO1
    • SCOD1
    • Spondylocostal dysostosis autosomal recessive
    see all

Properties

Images

  • Sanger Sequencing - Human DLL3 knockout HEK293T cell pellet (ab279136)
    Sanger Sequencing - Human DLL3 knockout HEK293T cell pellet (ab279136)
    Homozygous: 1 bp insertion in exon3

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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