Human DcR1 ELISA Kit (CD263) (ab46016)
Key features and details
- Sensitivity: 147 pg/ml
- Range: 312.5 pg/ml - 10000 pg/ml
- Sample type: Cell culture extracts, Serum
- Detection method: Colorimetric
- Assay type: Sandwich (quantitative)
- Reacts with: Human
Properties
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Storage instructions
Store at +4°C. Please refer to protocols. -
Components Identifier 1 x 96 tests 2 x 96 tests 10X Standard Diluent Buffer Black 1 x 15ml 1 x 25ml 200X Wash Buffer White 1 x 10ml 2 x 10ml Biotinylated Antibody Diluent Red 1 x 7ml 1 x 13ml Biotinylated anti-DcR1 Red 1 x 400µl 2 x 400µl Chromogen TMB Substrate Solution 1 x 11ml 1 x 24ml DcR1 Microplate (12 x 8 well strips) 1 unit 2 units DcR1 Standard (Lyophilized) Yellow 2 vials 4 vials HRP Diluent Red 1 x 12ml 1 x 23ml Stop Reagent Black 1 x 11ml 2 x 11ml Streptavidin-HRP 2 x 5µl 4 x 5µl -
Research areas
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Relevance
DcR1 is a member of the TNF-receptor superfamily. It contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. It is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. -
Cellular localization
Cell membrane; lipid-anchor; GPI-anchor -
Alternative names
- CD263
- DCR1
- Decoy receptor 1
see all -
Database links
- Entrez Gene: 8794 Human
- SwissProt: O14798 Human
Images
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Typical Standard Curve
Representative Standard Curve using ab46016