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Human BAMBI (NMA) knockout HEK293T cell pellet (ab279203)

Overview

  • Product name

    Human BAMBI (NMA) knockout HEK293T cell pellet
    See all BAMBI/NMA kits

  • Product overview

    Abcam’s knockout cell pellets give you access to native proteins, without the need to culture cells. Our knockout cell pellets are prepared from our single-gene knockout cell lines and provide an additional offering to our cell lysates.

    Cells are snap-frozen to provide high quality pellets that are suitable for extraction with alternative lysis buffers or for preparation of lysates from subcellular fractions. Our knockout cell pellets are suitable for a variety of applications, including PCR, gene expression profiling and DNA library preparation.

  • Parental Cell Line

    HEK293T

  • Organism

    Human

  • Mutation description

    Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 1.

  • Passage number

  • Knockout validation

    Sanger Sequencing

  • Notes

    Pellet size: 5 million cells/vial.

    This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our limited use license and patent pages.

Properties

Target

  • Function

    Negatively regulates TGF-beta signaling.

  • Tissue specificity

    High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.

  • Sequence similarities

    Belongs to the BAMBI family.

  • Developmental stage

    Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines.

  • Cellular localization

    Membrane.
  • Information by UniProt

  • Alternative names

    • BAMBI
    • BAMBI_HUMAN
    • BMP and activin membrane bound inhibitor homolog
    • BMP and activin membrane-bound inhibitor homolog
    • NMA
    • Non metastatic gene A protein
    • Non-metastatic gene A protein
    • Putative transmembrane protein NMA
    see all

Properties

Images

  • Sanger Sequencing - Human BAMBI (NMA) knockout HEK293T cell pellet (ab279203)
    Sanger Sequencing - Human BAMBI (NMA) knockout HEK293T cell pellet (ab279203)
    Homozygous: 1 bp insertion in exon 1

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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