GW 2580, cFMS RTK inhibitor (ab142096)
Key features and details
- Selective cFMS RTK inhibitor. Cell-permeable.
- CAS Number: 870483-87-7
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GW 2580, cFMS RTK inhibitor -
Description
Selective cFMS RTK inhibitor. Cell-permeable. -
Biological description
Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC50 = 0.2 μM) and LPS-induced TNF-α production in vivo. Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.
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Purity
> 99% -
CAS Number
870483-87-7 -
Chemical structure
Properties
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Chemical name
5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine -
Molecular weight
366.42 -
Molecular formula
C20H22N4O3 -
PubChem identifier
11617559 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC -
Source
Synthetic
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Research areas
