GSK484, PAD4 inhibitor (ab223598)
Key features and details
- Potent, reversible inhibitor of PAD4
- CAS Number: 1652591-81-5
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GSK484, PAD4 inhibitor -
Description
Potent, reversible inhibitor of PAD4 -
Biological description
Potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC50 = 50 nM). Selective for PAD4 over PAD1-3. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is re-ordered to form a β-hairpin. It blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.
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Purity
> 98% -
General notes
Protect from air and moisture.
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CAS Number
1652591-81-5 -
Chemical structure
Properties
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Chemical name
((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride -
Molecular weight
510.03 -
Molecular formula
C27H31N5O3.HCl -
PubChem identifier
86340151 -
Storage instructions
Shipped at 4°C. Store at -20°C or -80°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1C2=C(C=C(C=C2OC)C(=O)N3CC[C@H]([C@H](C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl -
Source
Synthetic
