GSK-3787, PPARdelta antagonist (ab144575)
Key features and details
- Potent, selective, irreversible PPARδ antagonist
- CAS Number: 188591-46-0
- Purity: > 98%
- Soluble in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GSK-3787, PPARdelta antagonist -
Description
Potent, selective, irreversible PPARδ antagonist -
Biological description
Potent, selective, irreversible peroxisome proliferator-activated receptor delta (PPARδ) antagonist (IC50 = 130 nM). No affinity for PPARα or PPARγ. Orally active. Active in vivo and in vitro. -
Purity
> 98% -
CAS Number
188591-46-0 -
Chemical structure
Properties
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Chemical name
4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridyl]sulfonyl]ethyl]benzamide -
Molecular weight
392.78 -
Molecular formula
C15H12ClF3N2O3S -
PubChem identifier
2800647 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=CC=C1C(=O)NCCS(=O)(=O)C2=NC=C(C=C2)C(F)(F)F)Cl -
Source
Synthetic
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Research areas