Astana Biomed Group, an authorized Abcam distributor in Central Asia

GF 109203X (Bisindolylmaleimide i), PKC inhibitor (ab144264)

Key features and details

  • Potent, selective PKC inhibitor. Potent GSK-3 inhibitor. Potent 5-HT3 antagonist.
  • CAS Number: 133052-90-1
  • Purity: > 98%
  • Soluble in DMSO to 25 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    GF 109203X (Bisindolylmaleimide i), PKC inhibitor

  • Description

    Potent, selective PKC inhibitor. Potent GSK-3 inhibitor. Potent 5-HT3 antagonist.

  • Alternative names

    • Bisindolylmaleimide I

  • Biological description

    Potent, selective PKC inhibitor (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Potent GSK-3 inhibitor (IC50 = 360 nM). Potent 5-HT3 antagonist (Ki = 29.5 nM). Shows anti-inflammatory effects in vivo.

  • Purity

    > 98%

  • CAS Number

    133052-90-1

  • Chemical structure

    Chemical Structure

Properties

Images

  • Functional Studies - GF 109203X (Bisindolylmaleimide i), PKC inhibitor (ab144264)
    Functional Studies - GF 109203X (Bisindolylmaleimide i), PKC inhibitor (ab144264)
    1.5 x 10e7 THP-1 cells were incubated with 100 nM GF 109203X (ab144264) or Ro 31-8220 mesylate (ab120374) for 30 minutes prior to activation with 10 µg x mL-1 PMA (Sigma) for 4 hours. Control cells were left without inhibitors or PMA. Cells were lysed in 1 mL of lysis buffer, and 30 µL were tested for PKC activity (duplicates; +/- SD).

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

© 2021 Astana Biomed Group LLP. All rights reserved.