Ganetespib (STA-9090) (ab273600)
Key features and details
- Potent Hsp90 inhibitor
- CAS Number: 888216-25-9
- Purity: > 98%
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ganetespib (STA-9090) -
Description
Potent Hsp90 inhibitor -
Alternative names
- STA-9090
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Biological description
Potent Hsp90 inhibitor (IC50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC50 of 43 nM.
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Purity
> 98% -
CAS Number
888216-25-9 -
Chemical structure
Properties
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Chemical name
5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol5-yl)-3H-1,2,4-triazol-3-one
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Molecular weight
364.40 -
Molecular formula
C20H20N4O3 -
PubChem identifier
135564985 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 100 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O -
Source
Synthetic
Images
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Chemical Structure - Ganetespib (STA-9090) (ab273600)
Chemical structure of Ganetespib (STA-9090), 888216-25-9