Galunisertib (LY2157299), TGFB kinase antagonist (ab254448)
Key features and details
- Highly potent TGF-beta kinase antagonist
- CAS Number: 700874-72-2
- Purity: > 98%
Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Galunisertib (LY2157299), TGFB kinase antagonist -
Description
Highly potent TGF-beta kinase antagonist -
Alternative names
- LY2157299
-
Biological description
Highly potent, TGF-beta kinase (ALK5) inhibitor (IC50 = 56 nM). Downregulates Smad2 phosphorylation. Increases VEGF-induced HUVEC cell migration. Enhances anti-neuroblastoma activity of Dinuxtuximab (anti-GD2 antibody) with natural killer cells. Reverses supression of human T cell proliferation induced by TGF-beta and regulatory T cells. Improves tumour growth inhibition and regression in colon carcinoma models. ALK4 and ALK5 (TGFβRI) inhibitor; component of growth media for urothelial organoids.
-
Purity
> 98% -
General notes
Solutions in DMSO may be stored at -20°C for up to 1 month.
-
CAS Number
700874-72-2 -
Chemical structure
Properties
-
Chemical name
4-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
-
Molecular weight
369.43 -
Molecular formula
C22H19N5O -
PubChem identifier
10090485 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM
-
Handling
Refer to SDS for more information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC1=CC=CC(=N1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N -
Source
Synthetic
-
Research areas
