G5, Ubiquitin Isopeptidase Inhibitor I (ab145967)
Key features and details
- Proteasome inhibitor
- CAS Number: 108477-18-5
- Purity: > 97%
Soluble in a 1:3 solution of DMSO:PBS. Please see Handling instructions.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
G5, Ubiquitin Isopeptidase Inhibitor I -
Description
Proteasome inhibitor -
Alternative names
- 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one
- AC1NZVX0
- CHEMBL3410535
see all -
Biological description
Cell-permeable cross-conjugated α,β-unsaturated dienone compound reported to induce caspase activation and apoptosis (IC50 = 1.76 and 1.6 µM in E1A and E1A/C9DN cells respectively) via an apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5.
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Purity
> 97% -
CAS Number
108477-18-5 -
Chemical structure
Properties
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Chemical name
3,5-Bis[(4-nitrophenyl)methylene]-2,3,5,6-tetrahydro-4H-thiopyran-4-one-1,1-dioxide
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Molecular weight
414.40 -
Molecular formula
C19H14N2O7S -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in a 1:3 solution of DMSO:PBS. Please see Handling instructions.
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Handling
For maximum solubility we recommend this compound be dissolved in DMSO and then diluted with aqueous buffer of choice. This compound has a solubility of approximately 0.25 mg/ml in a 1:3 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day. Also, DMSO solution needs to be purged with an inert gas for stability.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
