Fumagillin, methionine aminopeptidase-2 (MetAP2) inhibitor (ab141527)
Key features and details
- Potent, selective and covalent methionine aminopeptidase-2 (MetAP2) inhibitor. Anti-angiogenic.
- CAS Number: 23110-15-8
- Purity: > 95%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Fumagillin, methionine aminopeptidase-2 (MetAP2) inhibitor -
Description
Potent, selective and covalent methionine aminopeptidase-2 (MetAP2) inhibitor. Anti-angiogenic. -
Biological description
Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2) (IC50 = 9.2 nM). Anti-angiogenic. Inhibits endothelial cell proliferation. Inhibits neovascularization and reduces diet-induced obesityin vivo. Orally active. -
Purity
> 95% -
CAS Number
23110-15-8 -
Chemical structure
Properties
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Chemical name
10-[[5-Methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro
[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid -
Molecular weight
458.50 -
Molecular formula
C26H34O7 -
PubChem identifier
3430 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C -
Source
Synthetic
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Research areas
